Is Blood Sugar Dysregulation Related To Chronic Pelvic Pain?

Is blood sugar instability related to chronic pain, especially chronic pelvic pain?

The short answer is, “Yes!”

Usually, until a woman is diagnosed with pre-diabetes or diabetes, she doesn’t know that she has blood sugar instability. But, there are some simple ways to determine if your patient’s blood sugar instability and/or insulin resistance is related to her pain.

When mindfully listening to your patient share her health history, consider the following clues to blood sugar/ insulin instability:

  • First, your patient should feel stable energy, and not extremely hungry through the day. If she feels “hangry” – uncomfortable hunger, mood instability, fatigue, or grumpiness that is relieved by eating, that’s a clear sign of blood sugar instability.
  • When eating induces either fatigue or leads to a significant improvement in energy, that’s a sign of blood sugar instability.
  • She should be able to easily wait at least 6 hours between meals, without needing a snack.
  • Sugar cravings are a sure sign of blood sugar instability.
  • And,your patient should be able to sleep through the night without waking between 2:00am and 4:00am, sometimes even waking up hungry.
Do you want to learn more about specific strategies for recognizing early stage blood sugar instability, and learn nutrition and lifestyle medicine strategies to balance blood sugar? Click here to learn more.

Blood Sugar Instability and Chronic Pelvic Pain

Once you identify that there is an issue with blood sugar instability and/or insulin resistance, consider the research on the connections between blood sugar instability/ insulin resistance and chronic pelvic pain.

In rats, a bidirectional relationship has been found between nerve injury and hypersensitivity, and insulin resistance (Zhai, et al., 2016). In other words, insulin resistance can render the nerve injury more hypersensitive (which isn’t surprising), and nerve compression injuries can exacerbate insulin resistance. This was initially surprising to me, but when you consider that pain itself is a stressor to the hypothalamic-pituitary-adrenal (HPA) axis, that make sense. To learn more about the connection between the HPA axis and pain, click here.

Chronic back and neck pain, especially when it’s more severe, is associated with diabetes (Dario, et a;., 2017). But, the underlying mechanism of why those with type 2 diabetes suffer more with chronic back and neck pain is not clear.

Women with insulin resistance (determined by fasting insulin levels) showed lower electromyographic activity of the pelvic floor muscles (Mucussi et al., 2015), while this may or may not relate to pelvic pain, it could certainly be a factor in incontinence or pelvic organ prolapse.

Strategies to Improve Blood Sugar Stability and Relieve Associated Chronic Pain

  • Recommend a rehab programs of at least 4 weeks duration, to significantly decrease both insulin concentrations and pain, this has specifically been shown in morbidly obese populations (Doury-Panchout et al., 2017)
  • Reduce or eliminate sugar and sweeteners from the diet.
  • Increase vegetables in the diet to 8-10 servings daily
  • Consider having “Dinner for Breakfast” (instead of a sweet breakfast like bagels, cereal, or muffins.)

Some recipe ideas to start the day with less stress to your patient’s insulin receptors, and HPA axis:

Do you want to learn more about specific strategies for recognizing early stage blood sugar instability, and learn nutrition and lifestyle medicine strategies to balance blood sugar? Click here to learn more.


Dario, A, Ferreira, M, Refshauge, K, Harmer, A, Sanchez-Romero, J, Perez-Riquelme, F, Cisneros, L, Ordonana, J, & Ferreira, P (2017) Mapping the association between back pain and type 2 diabetes: A cross-sectional and longitudinal study of adult Spanish twins, PLoS One, 12(4): e0174757. doi: [10.1371/journal.pone.0174757]

Doury-Panchout, F, Metivier, J-C, Nardoux, J, & Fouquet, B (2017) Visceral obesity and chronic pain: effect of a 4-week rehabilitation program on adipokines and insulin resistance, J Exerc Rehabil, 13(4): 464–471.

Mucussi, MT, Freitas, RP, Angelo, PH, Soares, EM, Lemos, ™, & Maranhao, ™ (2015) Evaluation of the relationship between the pelvic floor muscles and insulin resistance, Diabetes Metab Syndr Obes. 8,409–413.

Zhai, X, Sun, C, Rong, P, Li, S, McCabe MF, Wang, X, Mao, J, & Wang, S (2016) A Correlative Relationship Between Chronic Pain and Insulin Resistance in Zucker Fatty Rats: Role of Downregulation of Insulin Receptors, J Pain, 17(4):404-13. doi: 10.1016/j.jpain.2015.12.003.

2 thoughts on “Is Blood Sugar Dysregulation Related To Chronic Pelvic Pain?

  1. I recently found out I have NASH and my doctor told me I needed to change my diet. After I changed my diet cutting out all sugars and only eating Whole Foods and drinking only water I started to feel a chronic UTI pain. You would think I would feel better? No, this pain is debilitating and I kept testing as no UTI at the doctors. This past Monday I saw a urologist and he diagnosed me with IC. I felt unsettled because the doctor wasn’t truly listening to me. I noticed every time I would slip and eat something unhealthy the pain would go away. So I started testing it when I had my worst days I would go and eat some sugar and within an hour the symptoms went completely away. I don’t have diabetes and have been tested. But I feel at a lost because I don’t know what type of doctor to talk to and who would believe me that Sugar makes me feel better. And how to go about treating this so I don’t have a debilitating pain in my pelvic region but also can still heal my liver. Please help! I’m Desperate.

  2. I have reached this article as I am celebrating my birthday and after eating sugar after a long period of time my UTI type of pain has came back. I test negative for UTI but it’s the same kind of pain, with stinging when I urinate.. I also get it after I spend time in cold places. But now I realised there must be a connection between sweets and chronic pelvic pain. I don’t understand how nerves are affected but I will try to continue and reduce sugar from my diet..

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